Derivatives of 10-hydroxy-2-decenoic acid and use in a composition favorable in the desquamation of the skin and composition containing the same

Derivate der 10-hydroxy-2-decensäure und Anwendung in einer die Abschuppung begünstigende Komposition, und diese enthaltende Komposition

Nouveaux dérivés de l'acide 10-hydroxy-2-décénoique et utilisation dans une composition destinée à favoriser la desquamation de la peau, et composition le comprenant

Abstract

A 10-hydroxy-2-decenoic acid compound (I) is used as an active ingredient in a composition for promoting skin peeling and/or epidermal renewal and thus for combating skin aging. A compound of formula (I), or a salt or isomer of (I), is used as an active ingredient in a composition for promoting skin peeling and/or epidermal renewal and thus for combating skin aging: R1 = H, NR'R, OR3, or aryl or aralkyl optionally substituted by 1-18C alkyl, COR' or OR'; R', R = H, 1-4C alkyl, 3-4C alkenyl, cyclopentyl or cyclohexyl, or NR'R is a heterocycle or an amino acid or glucosamine residue; R3 = H; 1-18C alkyl or 2-18C alkenyl optionally substituted by one or more OH, NH2 and/or aminoalkyl groups or by a COOH or 2-19C alkoxycarbonyl group; or 1-18C perfluoroalkyl; R2 = H, 1-18C alkyl, 2-18C alkenyl, 1-18C perfluoroalkyl, 1-8C mono- or polyhydroxyalkyl, cyclopentyl, cyclohexyl, tetrahydropyranyl or COR4; R4 = 1-18C alkyl, 1-8C monohydroxyalkyl, 3-6C polyhydroxyalkyl (containing 2-5 OH groups), NR'R, or aryl or aralkyl optionally substituted by 1-18C alkyl, COR' or OR'; R' = H, OH or 1-18C alkyl; provided that when R2 is H then R3 cannot be N,N-dimethylaminoethyl, 2,3-dihydroxypropyl, 2,3-di(10-hydroxy-2-decenoyloxy)propyl, 3-(10-hydroxy-2-decenoyloxy)-2-hydroxypropyl or 2-(10-hydroxy-2-decenoyloxy)-3-(2-methoxyethoxymethoxy)propyl. Independent claims are also included for the following: (1) a composition for promoting skin peeling and/or epidermal renewal and thus for combating intrinsic and/or extrinsic skin aging, comprising at least one compound (I); (2) a nontherapeutic treatment process for promoting skin peeling and/or epidermal renewal and thus for combating intrinsic and/or extrinsic skin aging, comprising applying a cosmetic composition as in (1) to the skin; (3) new 10-hydroxy-2-decenoic acid derivatives of formula (I') and their salts and isomers: R'1 = H or a group of formula (i)-(iii): R'2 = H, hydroxybenzoyl, a group of formula (ii) or COCH(OH)R'5; R'5 = H, Me or C6H13; R'6 = COOH, ethoxycarbonyl, CH2OH or OH; R'7 = OH, 10-hydroxy-2-decenoyloxy or 2-methoxyethoxymethoxy; R'8 = OH or 2-methoxyethoxymethoxy; R'9 = 2-methoxyethoxymethoxy; R'10 = 10-hydroxy-2-decenoyloxy or 2-methoxyethoxymethoxy; provided that: (a) when R'1 is H then R'2 cannot be H and (b) when R'7 is 10-hydroxy-2-decenoyloxy then R'8 cannot be 2-methoxyethoxymethoxy.
L'invention concerne de nouveaux dérivés de l'acide 10-hydroxy-2-décénoique, l'utilisation en tant que composé actif dans une composition d'une quantité efficace d'acide 10-hydroxy-2-décénoique ou d'au moins l'un de ses dérivés, l'acide ou la composition étant destinés à favoriser la desquamation de la peau et/ou stimuler le renouvellement épidermique et/ou lutter contre le vieillissement de la peau. Elle se rapporte aussi à des compositions pour favoriser la desquamation de la peau et/ou stimuler le renouvellement épidermique et donc lutter contre le vieillissement cutané intrinsèque et/ou extrinsèque, ainsi qu'à un procédé de traitement non thérapeutique de la peau destiné à favoriser la desquamation et/ou lutter contre le vieillissement de la peau.

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